SOUTH CAROLINA: INBRE researcher publishes new study on neuropeptide galatin
SC INBRE researcher Mike Giuliano, College of Charleston, and lab have recently published, “The neuropeptide galanin adopts an irregular secondary structure,” in Biochemical and Biophysical Research Communications. Said Giuliano, “Happy to share the the outstanding work of CofC Chem undergrad researchers Rachel Wilkinson, Katie Kraichely, and Cecilia Hendy! [Thank you to] SC INBRE for their support of my lab, and flexibility in funding during the pandemic – that let me pay our first author and rockstar Rachel Wilkinson.”
Human galanin is a 30-residue neuropeptide targeted for development of analgesics, antidepressants, and anticonvulsants. While previous work from our group and others has already produced significant insights into galanin's N-terminal region, no extant structures of galanin in databases include its full-length sequence and the function of its C-terminus remains ambiguous.