DELAWARE: INBRE and COBRE researchers published in Journal of Neuroscience
Delaware INBRE-funded researcher Christine Charvet, COBRE Delaware Center for Neuroscience Research-funded researcher Brian Edlow and team were recently published in the Journal of Neuroscience. “We integrated gene expression with diffusion MR imaging to study the evolution of human brain pathways,” said Charvet of their paper, “Tracing modification to cortical circuits in human and non-human primates from high resolution tractography, transcription, and temporal dimensions.”
The neural circuits that support human cognition are a topic of enduring interest. Yet, there are limited tools available to map human brain circuits in the human and non-human primate brain. We found that frontal cortex circuitry development is extended in primates, and concomitant with an expansion in cortico-cortical pathways compared with mice in adulthood. Importantly, we found that these parameters varied relatively little across humans and studied primates. Our work demonstrates that integrating transcriptional and structural data across temporal dimensions is a robust approach to trace the evolution of brain pathways in primates.