KENTUCKY: INBRE research receives $445,390 NIH R15 grant
Dae-Sung Hwangbo, University of Louisville, has received a new NIH National Institute on Aging $445,390 R15 grant for his research project, “Genetic Mechanisms of Circadian Clock-Mediated Dietary Restriction in Drosophila.”
This grant is a result of Dae-Sung’s KY INBRE Investigator Development Award (2020-2021).
FROM THE ABSTRACT:
Dietary Restriction (DR), where caloric or diet intake is reduced but not to the point of malnutrition, extends lifespan and healthspan in model organisms from single cellular yeast to non-human primates. However, the molecular mechanisms by which DR delays aging and promotes health are not fully understood. This study is meritorious because it will generate outcomes that provide insight into how the circadian clock orchestrates environmental cues to promote health and longevity. This study also strengthens the research environment of undergraduate students at the University of Louisville because it is designed to be completed by a research team primarily composed of undergraduate students at the University.